ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between the findings by coronary computed tomography angiography (CCTA) and the risk factors for major adverse cardiac events (MACE).</p><p><b>METHODS</b>This cohort study involved 706 out-patients who received examination with CCTA between June, 2008 and April, 2011. The severity of coronary artery disease (CAD) was graded to normal, mild, moderate, severe, and revascularization. Pearson correlation analysis and ANOVA were used to evaluate the relationship between the risk factors for CAD and coronary plaques identified by CCTA, and the predictive accuracy was determined by the receiver-operating characteristic (ROC) curve.</p><p><b>RESULTS</b>Of the 706 patients, 58.63% were found to have abnormal CCTA findings. A older age, hypertension, hyperlipidemia, diabetes mellitus, cerebral infarction, CAD, and myocardial infarction were associated with an significantly increased incidence of coronary plaques (P<0.01). The Framingham score, LDL, HCY, IMT, HDL and TC were also significantly correlated with the severity of the coronary plaques (P<0.05). The ROC curves showed that Framingham risk score (0.845), Cr (0.766), HCY (0.697), IMT (0.693) and HDL (0.316) had greater predictive value for the occurrence of coronary plaques (P<0.001).</p><p><b>CONCLUSION</b>The Framingham risk score, Cr, HCY, IMT and HDL are validated by CCTA as the major coronary risk factors and can be used for screening of CAD.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Coronary Angiography , Methods , Coronary Artery Disease , Diagnostic Imaging , Cross-Sectional Studies , Risk Factors , Tomography, Spiral Computed , Tomography, X-Ray Computed , MethodsABSTRACT
Objective To investigate the change of blood pressure and heart rate in patients of essential hypertension combined with cervical spondylosis in head-up tilt and its potential mechanism. Methods The hypertensive patients were divided into cervical spondylosis group(23 cases) and without cervical spondylosis group (26 cases) by clinical symptom and X-ray machine,CT.MRI and color ultrasonography,then their blood pressure, blood glucose and lipid were measured,and the changes of blood pressure and heart rate were obtained in head-up tilt. Results There was significant difference of blood pressure change between the hypertensive with and without cervical spondylosis(4(-21 ～ 14 mm Hg v. s. -9(-27～-3)mm Hg,P<0. 01),and there was also difference of heart rate change between the hypertensive with and without cervical spondylosis(2(-1 ～14) bpm v. s. 5(-2 ～11) bpm, P < 0. 01). Conclusions There is no decline in blood pressure in the hypertensive with cervical spondylosis in head-up tilt and this might be due to the exciting of sympathetic nerve.
ABSTRACT
Objective To investigate the effect of antisense telomerase reverse transcriptase (TERT) on 5-hydroxytryptamine (5-HT) induced proliferation and cell cycle of pulmonary artery smooth muscle cells (PASMCs). Methods PASMCs were cultured and divided into four groups: control group (cultured in RPMI-1640 culture medium), 5-HT group (cultured in culture medium containing 5-HT), antisense oligonucleotide (ASODN) group (cultured in culture medium containing 5-HT and ASODN TERT), and sense oligonucleotide (SODN) group (cultured in culture medium containing 5-HT and SODN TERT). The apoptosis of PASMC was observed by fluorescence microscopy with Hoechst staining. Apoptosis and cell cycle was analyzed with flow cytometry. Expression of proliferated cell nuclear antigen (PCNA) was determined by immunohistochemistry staining. Results Hoechst staining showed that apoptosis in 5-HT group (161?33) was significantly higher than that in control group (63?16, P